Author: Colline Lapina; Mathieu Rodic; Denis Peschanski; SALMA MESMOUDI
Title: The potential genetic network of human brain SARS-CoV-2 infection Document date: 2020_4_6
ID: gk1t1dor_5
Snippet: In 2002 and 2003, studies on SARS patients established the presence of SARS-CoV particles in the brain, found in both neurons and gliocytes [9, 10, 11] . Based on experimental studies on transgenic mice, Netland et al. and Li et al. [12, 13] concluded that SARS-CoV and MERS-CoV is likely to enter the brain through olfactory nerves when administered intranasally. From there, viruses would promptly spread other areas of the brain, including thalamu.....
Document: In 2002 and 2003, studies on SARS patients established the presence of SARS-CoV particles in the brain, found in both neurons and gliocytes [9, 10, 11] . Based on experimental studies on transgenic mice, Netland et al. and Li et al. [12, 13] concluded that SARS-CoV and MERS-CoV is likely to enter the brain through olfactory nerves when administered intranasally. From there, viruses would promptly spread other areas of the brain, including thalamus and the brain stem. It should be noted that in mice infected with low inoculum doses of MERS-CoV, particles have been exclusively found in the brain, but not in the lungs. This indicates that the CNS infection was more decisive in the high mortality detected in infected mice [13].
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