Author: Pröbstel, Anne-Katrin; Schirmer, Lucas
Title: SARS-CoV-2-specific Neuropathology: Fact or Fiction? Cord-id: ubljpeia Document date: 2021_10_16
ID: ubljpeia
Snippet: Neurological symptoms and varying levels of central nervous system (CNS) immunopathology have been described in COVID-19. Recent reports suggest an increased level of innate immune activation associated with CNS border areas, as well as a compartmentalized cytokine response and dysregulated, auto-reactive CSF immune profile. However, it remains contested whether these changes reflect bystander effects of systemic inflammation or relate to CNS-specific viral infection. In this article, we summari
Document: Neurological symptoms and varying levels of central nervous system (CNS) immunopathology have been described in COVID-19. Recent reports suggest an increased level of innate immune activation associated with CNS border areas, as well as a compartmentalized cytokine response and dysregulated, auto-reactive CSF immune profile. However, it remains contested whether these changes reflect bystander effects of systemic inflammation or relate to CNS-specific viral infection. In this article, we summarize some of the key findings pertaining this ongoing debate and highlight directions for future investigation.
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