The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods

Ying hui Huang; Si jun Meng; Yi Zhang; Shui sheng Wu; Yu Zhang; Ya wei Zhang; Yi xiang Ye; Qi feng Wei; Nian gui Zhao; Jian ping Jiang; Xiao ying Ji; Chun xia Zhou; Chao Zheng; Wen Zhang; Li zhong Xie; Yong chao Hu; Jian quan He; Jian Chen; Wang yue Wang; Chang hua Zhang; Liming Cao; Wen Xu; Yunhong Lei; Zheng hua Jian; Wei ping Hu; Wen juan Qin; Wan yu Wang; Yu long He; Hang Xiao; Xiao fang Zheng; Yi Qun Hu; Wen Sheng Pan; Jian feng Cai

A total of 10 patients were included in this study, ranging in age from 30 to 82 years old, mostly male (70%), all of whom had an epidemiological history of contact with suspected or confirmed patients. The number of patients was limited since current situation was serious and it was safe to detect the results through patients in one ward. The most common initial symptoms were similar to recent studies, which included respiratory symptoms (6/10) or fever (1/10) with highest temperature reaching 39.2℃. One patient was asymptomatic and had only transient fever during treatment, with a maximum temperature of 37.5℃. Two other patients had the first symptoms of digestive system, one of which was diarrhea and the other was abdominal discomfort. However, both patients developed cough and fever successively before admission. Before admission to NPFH, all patients were isolated and observed in regional primary medical institutions. All patients had at least one nucleic acid test, and 7 patients had a positive test at the first time, the other 3 patients had a negative test repeated the test after 24 hours. The median incubation period from primary symptoms to viral test positive was 7 days (interquartile range 3-15 days). Once the nucleic acid test is found positive, the patient was immediately transferred to COV-MG of NPFH for intensive treatment. Chest X-ray or CT were detected before and after admission for each patient. Local or bilateral ground glass shadows, infiltrating shadows or stromal changes were found in all patients' CT, of which 80% patients accumulated bilateral lungs. Based on further examination which were done after admission, three patients were diagnosed with severe type and seven patients were diagnosed as common type, all of whom did not develop to comorbid conditions.