Selected article for: "DUB activity and DUBmut virus"
Author: Xufang Deng; Yafang Chen; Anna M. Mielech; Matthew Hackbart; Kristina R. Kesely; Robert C. Mettelman; Amornrat O’Brien; Mackenzie E. Chapman; Andrew D. Mesecar; Susan C. Baker
Title: Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus
  • Document date: 2019_9_25
    • ID: l3qp0n9f_10
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/782409 doi: bioRxiv preprint of the DUBmut virus, but that this interferon profile is not associated with reduced production of 197 infectious particles in either DBT cells or BMDMs. In the present study, we aimed to investigate the roles of PLP2 DUB activity during 216 coronavirus infection. Through structure-guided mutagenesis, w.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/782409 doi: bioRxiv preprint of the DUBmut virus, but that this interferon profile is not associated with reduced production of 197 infectious particles in either DBT cells or BMDMs. In the present study, we aimed to investigate the roles of PLP2 DUB activity during 216 coronavirus infection. Through structure-guided mutagenesis, we identified residues of MHV 217 PLP2 that mediates its interaction with ubiquitin. By mutating the residue Asp-1772 to Ala 218 All rights reserved. No reuse allowed without permission.

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