Author: Umar Faruq Chowdhury; Mohammad Umer Sharif Shohan; Kazi Injamamul Hoque; Mirza Ashikul Beg; Mohammad Ali Moni; Mohammad Kawsar Sharif Siam
Title: A Computational Approach to Design Potential siRNA Molecules as a Prospective Tool for Silencing Nucleocapsid Phosphoprotein and Surface Glycoprotein Gene of SARS-CoV-2 Document date: 2020_4_12
ID: exoc6xvt_11
Snippet: Conserved sequences were put to siDirect web server to identify possible targets and to generate 238 corresponding siRNAs. siDirect performs the task in three distinct steps -highly functional siRNA 239 selection, seed-dependent off-target effects reduction, near-perfect matched genes elimination. 240 siRNA targets were found in 18 conserved regions, 5 nucleocapsid phosphoprotein (Supplementary 241 Table 4 ) and 13 surface glycoprotein (Supplem.....
Document: Conserved sequences were put to siDirect web server to identify possible targets and to generate 238 corresponding siRNAs. siDirect performs the task in three distinct steps -highly functional siRNA 239 selection, seed-dependent off-target effects reduction, near-perfect matched genes elimination. 240 siRNA targets were found in 18 conserved regions, 5 nucleocapsid phosphoprotein (Supplementary 241 Table 4 ) and 13 surface glycoprotein (Supplementary Table 5 the prediction of prospective secondary structure and determination of free energy of corresponding 264
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