Author: Alisher M Kariev; Michael E Green
Title: The Role of Proton Transport in Gating Current in a Voltage Gated Ion Channel, as Shown by Quantum Calculations Document date: 2018_7_19
ID: cyxdy7hg_73
Snippet: Both KcsA and K v 1.2 have linear ln[K + ] vs ln σ curves, which should correspond to a barrier, as we discussed earlier (Fig. 3 ). If we compare the need for a barrier to the steps for an oscillating gate, the most obvious step to have the barrier is aïƒ b in Fig. 9 . Here an ion from solution must enter the gate, bring the gate, with its water, to the position that complexes the ion, and rearrange the water in the cavity. Thus the model is con.....
Document: Both KcsA and K v 1.2 have linear ln[K + ] vs ln σ curves, which should correspond to a barrier, as we discussed earlier (Fig. 3 ). If we compare the need for a barrier to the steps for an oscillating gate, the most obvious step to have the barrier is aïƒ b in Fig. 9 . Here an ion from solution must enter the gate, bring the gate, with its water, to the position that complexes the ion, and rearrange the water in the cavity. Thus the model is consistent with the data; since the free energy gradient should affect an ion at the gate, but not further up the pore, the concentration dependence seems to require that that the barrier demonstrated by Fig. 3 be at the intracellular end of the pore.
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