Author: José L. Martínez; Francesca Arnoldi; Elisabeth M. Schraner; Catherine Eichwald; Daniela Silva-Ayala; Eunjoo Lee; Elizabeth Sztul; Óscar R. Burrone; Susana López; Carlos F. Arias
Title: The guanine nucleotide exchange factor GBF1 participates in rotavirus replication Document date: 2019_4_29
ID: jkjkkjrf_11
Snippet: After 12 hpi the cells were harvested, and the viral yield was determined. Silencing the 160 expression of GBF1 reduced the yield of viral progeny by about 70% as compared to that 161 produced in cells transfected with control, irrelevant siRNA (Fig 1D, right) . These results, 162 together with the fact that GCA decreases RRV replication to a level similar to that observed 163 with BFA, strongly suggest that GBF1 activity might be involved in the.....
Document: After 12 hpi the cells were harvested, and the viral yield was determined. Silencing the 160 expression of GBF1 reduced the yield of viral progeny by about 70% as compared to that 161 produced in cells transfected with control, irrelevant siRNA (Fig 1D, right) . These results, 162 together with the fact that GCA decreases RRV replication to a level similar to that observed 163 with BFA, strongly suggest that GBF1 activity might be involved in the replication cycle of the viral yield by more than 90%; the inhibitory effect was less evident at subsequent times 170 post-infection. When added at 4 hpi, the drugs reduced only around 60% of the viral progeny 171 All rights reserved. No reuse allowed without permission.
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