Author: Jillian N Whelan; Joshua Hatterschide; David M. Renner; Beihua Dong; Robert H Silverman; Susan R Weiss
Title: The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production Document date: 2019_11_24
ID: f9mpkzni_14
Snippet: RNase L deletion decreased circularity and increased diameter of RFs, distinct from the 156 densely concentrated RF phenotype observed in WT cells ( Figure 2AB&C) . We 157 observed this trend of viral RF diffusion in RNase L KO cells as early as 16hpi through 158 30hpi, in two different RNase L KO clones ( Figure S1 ). We performed all future analyses 159 on cells fixed at 20hpi, which provides adequate infected cells for quantification purposes,.....
Document: RNase L deletion decreased circularity and increased diameter of RFs, distinct from the 156 densely concentrated RF phenotype observed in WT cells ( Figure 2AB&C) . We 157 observed this trend of viral RF diffusion in RNase L KO cells as early as 16hpi through 158 30hpi, in two different RNase L KO clones ( Figure S1 ). We performed all future analyses 159 on cells fixed at 20hpi, which provides adequate infected cells for quantification purposes, 160 but is early enough for examination of a uniform stage of the viral replication cycle across 161 All rights reserved. No reuse allowed without permission.
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