Selected article for: "ability virus and action mechanism"
Author: Lea Gaucherand; Brittany K. Porter; Summer K. Schmaling; Christopher Harley Rycroft; Yuzo Kevorkian; Craig McCormick; Denys A. Khaperskyy; Marta Maria Gaglia
Title: The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression
  • Document date: 2018_10_14
    • ID: 8k7w467p_31
    Snippet: show that the ability of the virus to regulate host gene expression is severely reduced in the 464 absence of PA-X. Moreover, we have uncovered a unique mechanism of host RNA targeting that 465 can allow PA-X to not only distinguish between host and viral targets, but also among cellular 466 targets. For example, the intronless mRNA TAF7, which we examined in Figures 2B, 2C , is a 467 component of Pol II pre-initiation complexes. Therefore, the s.....
    Document: show that the ability of the virus to regulate host gene expression is severely reduced in the 464 absence of PA-X. Moreover, we have uncovered a unique mechanism of host RNA targeting that 465 can allow PA-X to not only distinguish between host and viral targets, but also among cellular 466 targets. For example, the intronless mRNA TAF7, which we examined in Figures 2B, 2C , is a 467 component of Pol II pre-initiation complexes. Therefore, the selectivity of PA-X could have 468 repercussions for the viral replication cycle. By continuing to define the PA-X mechanism of 469 action, we will gain important insights into how host shutoff allows the virus to usurp host 470 biosynthetic machinery, and expand our knowledge of the link between PA-X and IAV 471 pathogenesis. 472 473 474 All rights reserved. No reuse allowed without permission.

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