Author: Lea Gaucherand; Brittany K. Porter; Summer K. Schmaling; Christopher Harley Rycroft; Yuzo Kevorkian; Craig McCormick; Denys A. Khaperskyy; Marta Maria Gaglia
Title: The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression Document date: 2018_10_14
ID: 8k7w467p_8
Snippet: When we analyzed the effect of PA-X on the two mRNAs, we found that PA-X down-regulated 252 the IFN-λ2 mRNA expressed from the full genomic region ( Figure 5B ). However, the levels of 253 the same IFN-λ2 mRNA expressed from an intronless cDNA construct were only minimally 254 reduced ( Figure 5B ). In both conditions, the control luciferase reporter was down-regulated by 255 PA-X. PA-X proteins from the 2009 pandemic H1N1 strains (such as A/Ca.....
Document: When we analyzed the effect of PA-X on the two mRNAs, we found that PA-X down-regulated 252 the IFN-λ2 mRNA expressed from the full genomic region ( Figure 5B ). However, the levels of 253 the same IFN-λ2 mRNA expressed from an intronless cDNA construct were only minimally 254 reduced ( Figure 5B ). In both conditions, the control luciferase reporter was down-regulated by 255 PA-X. PA-X proteins from the 2009 pandemic H1N1 strains (such as A/California/7/09(H1N1) 256 (CA/7) and A/Tennessee/1-560/2009) and the Udorn H3N2 strain also preferentially degraded 257 intron-containing target RNAs ( Figure 5C ). These results confirm the prediction based on our 258
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