Selected article for: "crude material and general procedure"

Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
  • Document date: 2020_2_10
  • ID: 7n8p9okf_83
    Snippet: Synthesis of compounds 9 (general procedure). Compound 8 (0.40 mmol) was dissolved in CH2Cl2, and then acetic acid (0.028 g, 0.47 mmol) and isocyanide (0.43 mmol) were added successively to the solution. The reaction was stirred at 20 o C for 24 h. Then the solvent was evaporated and the crude material purified on silica, eluted with a mixture of CH2Cl2/MeOH (20/1) to give the product 9 (46-84%)......
    Document: Synthesis of compounds 9 (general procedure). Compound 8 (0.40 mmol) was dissolved in CH2Cl2, and then acetic acid (0.028 g, 0.47 mmol) and isocyanide (0.43 mmol) were added successively to the solution. The reaction was stirred at 20 o C for 24 h. Then the solvent was evaporated and the crude material purified on silica, eluted with a mixture of CH2Cl2/MeOH (20/1) to give the product 9 (46-84%).

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