Author: Kurtovic, Liriye; Beeson, James G.
Title: Complement factors in COVID-19 therapeutics and vaccines Cord-id: wewaoja6 Document date: 2020_12_13
ID: wewaoja6
Snippet: Complement is integral to a healthy functioning immune system and orchestrates various innate and adaptive responses against viruses and other pathogens. Despite its importance, the potential beneficial role of complement in immunity to SARS-CoV-2 has been overshadowed by reports of extensive complement activation in severe COVID-19 patients. Here, we hypothesize that complement may also have a protective role and could function to enhance virus neutralization by antibodies, promote virus phagoc
Document: Complement is integral to a healthy functioning immune system and orchestrates various innate and adaptive responses against viruses and other pathogens. Despite its importance, the potential beneficial role of complement in immunity to SARS-CoV-2 has been overshadowed by reports of extensive complement activation in severe COVID-19 patients. Here, we hypothesize that complement may also have a protective role and could function to enhance virus neutralization by antibodies, promote virus phagocytosis by immune cells, and lysis of virus. These functions might be exploited in the development of effective therapeutics and vaccines against SARS-CoV-2.
Search related documents:
Co phrase search for related documents- activity little and acute phase: 1, 2
- activity little and acute respiratory syndrome: 1, 2, 3, 4, 5, 6
- activity little and address need: 1
- activity little and low concentration: 1
- acute ards respiratory distress syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute ards respiratory distress syndrome and adaptive immunity: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- acute ards respiratory distress syndrome and adaptive innate response: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and address need: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and low concentration: 1
- acute ards respiratory distress syndrome report and adaptive innate: 1
- acute phase and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8
- acute phase and adaptive immunity: 1, 2, 3, 4, 5, 6, 7
- acute phase and adaptive immunity development: 1
- acute phase and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute phase and adaptive innate response: 1
- acute phase and address need: 1, 2
- acute respiratory syndrome and additional marker: 1, 2
- acute respiratory syndrome and address need: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date