Author: Edwards, Robert J; Mansouri, Katayoun; Stalls, Victoria; Manne, Kartik; Watts, Brian; Parks, Rob; Janowska, Katarzyna; Gobeil, Sophie M. C.; Kopp, Megan; Li, Dapeng; Lu, Xiaozhi; Mu, Zekun; Deyton, Margaret; Oguin, Thomas H; Sprenz, Jordan; Williams, Wilton; Saunders, Kevin; Montefiori, David; Sempowski, Gregory D.; Henderson, Rory; Alam, Munir; Haynes, Barton F.; Acharya, Priyamvada
Title: Cold sensitivity of the SARS-CoV-2 spike ectodomain Cord-id: wny6djph Document date: 2020_10_13
ID: wny6djph
Snippet: The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its Receptor Binding Domain in two conformations: receptor-accessible “up†or receptor-inaccessible “down†conformations. Here, we report that the commonly used stabilized S ectodomain construct “2P†is sensitive to cold temperature, and that this cold sensitivity is resolved in a “down†state stabilized spike. Our results will impact structural, functional and vaccine studies that use t
Document: The SARS-CoV-2 spike (S) protein, a primary target for COVID-19 vaccine development, presents its Receptor Binding Domain in two conformations: receptor-accessible “up†or receptor-inaccessible “down†conformations. Here, we report that the commonly used stabilized S ectodomain construct “2P†is sensitive to cold temperature, and that this cold sensitivity is resolved in a “down†state stabilized spike. Our results will impact structural, functional and vaccine studies that use the SARS-CoV-2 S ectodomain.
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