Maculopapular eruptions associated to COVID‐19: a subanalysis of the COVID‐Piel study

Català , Alba; Galván‐Casas, Cristina; Carretero‐Hernández, Gregorio; Rodríguez‐Jiménez, Pedro; Fernández‐Nieto, Daniel; Rodríguez‐Villa, Ana; Navarro‐Fernández, Íñigo; Ruiz‐Villaverde, Ricardo; Falkenhain‐López, Daniel; Llamas‐Velasco, Mar; Carnero‐Gonzalez, Lucía; García‐Gavin, Juan; Baniandrés, Ofelia; González‐Cruz, Carlos; Morillas‐Lahuerta, Víctor; Cubiró, Xavier; Figueras, Ignasi; Selda‐Enriquez, Gerald; Fustà ‐Novell, Xavier; Roncero‐Riesco, Mónica; Burgos‐Blasco, Patrícia; Romaní, Jorge; Solà ‐Ortigosa, Joaquim; García‐Doval, Ignacio

BACKGROUND: A previous study has defined the maculopapular subtype of manifestations of COVID‐19. OBJECTIVES: To describe and classify maculopapular eruptions associated with COVI‐19. METHODS: We carried out a subanalysis of the maculopapular cases found in the previous cross‐sectional study. Using a consensus, we defined 7 clinical patterns. We described patient demographics, the therapy received by the patient and the characteristics of each pattern. RESULTS: Consensus lead to the description of 7 major maculopapular patterns: Morbilliform (45.5%), Other maculopapular (20.0%), Purpuric (14.2%), Erythema multiforme‐like (9.7%), Pytiriasis rosea‐like (5.7%), Erythema elevatum diutinum‐like (2.3%) and Perifollicular (2.3%). In most cases, maculopapular eruptions were coincident (61.9%) or subsequent (34.1%) to the onset of other COVID‐19 manifestations. The most frequent were cough (76%), dyspnea (72%), fever (88%), and astenia (62%). Hospital admission due to pneumonia was frequent (61%). Drug intake was frequent (78%). Laboratory alterations associated with maculo‐papular eruptions were high C‐reactive protein, high D‐Dimer, lymphopenia, high ferritin, high LDH, and high IL‐6. LIMITATIONS: The impossibility to define the cause–effect relationship of each pattern. CONCLUSION: We provide a description of the cutaneous maculopapular manifestations associated with COVID‐19. The cutaneous manifestations of COVID‐19 are wide‐ranging and can mimic other dermatoses. This article is protected by copyright. All rights reserved.