Author: Jacob W. Myerson; Priyal N. Patel; Nahal Habibi; Landis R. Walsh; Yi-Wei Lee; David C. Luther; Laura T. Ferguson; Michael H. Zaleski; Marco E. Zamora; Oscar A. Marcos-Contreras; Patrick M. Glassman; Ian Johnston; Elizabeth D. Hood; Tea Shuvaeva; Jason V. Gregory; Raisa Y. Kiseleva; Jia Nong; Kathryn M. Rubey; Colin F. Greineder; Samir Mitragotri; George S. Worthen; Vincent M. Rotello; Joerg Lahann; Vladimir R. Muzykantov; Jacob S. Brenner
Title: Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment Document date: 2020_4_18
ID: ezrkg0dc_49
Snippet: We induced CPE in mice via prolonged IV propranolol infusion. 50 Edema was confirmed via CT imaging of inflated lungs ex vivo and in situ. Three-dimensional reconstructions of chest CT images were partitioned to distinguish airspace and lowdensity tissue, as in normal lungs (white, yellow, and light orange signal in Figure 5a ), from high-density tissue and edema (red and black/transparent signal in Figure 5a ). Quantification of CT attenuation a.....
Document: We induced CPE in mice via prolonged IV propranolol infusion. 50 Edema was confirmed via CT imaging of inflated lungs ex vivo and in situ. Three-dimensional reconstructions of chest CT images were partitioned to distinguish airspace and lowdensity tissue, as in normal lungs (white, yellow, and light orange signal in Figure 5a ), from high-density tissue and edema (red and black/transparent signal in Figure 5a ). Quantification of CT attenuation and gaps in the reconstructed three-dimensional lung images indicated profuse edema in lungs afflicted with model cardiogenic pulmonary edema ( Figure 5A 200 nm LDNGs were traced in mice with induced cardiogenic pulmonary edema. LDNGs accumulated in the edematous lungs at 14.52 %ID/g concentration, statistically indistinguishable from lung uptake in naïve mice and an order of magnitude lower than the level of lung uptake in mice treated with IV LPS ( Figure 5C ).
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