Author: Ryan M. Carey; Jenna R. Freund; Benjamin M. Hariri; Nithin D. Adappa; James N. Palmer; Robert J. Lee
Title: Altered polarization of PAR-2 signaling during airway epithelial remodeling Document date: 2020_1_9
ID: 8iet67u3_34
Snippet: The above data suggest that epithelial de-differentiation or remodeling affects the polarization of PAR-2 and may sensitize epithelial cells to protease allergens by allowing apical PAR-2 activation. We tested if other alterations of epithelial development and ciliogenesis cause this phenotype. We used cigarette smoke condensate (CSC), shown to inhibit ciliogenesis in nasal ALIs. 17 Human ALIs cultured in the presence of 10-30 µg/ml CSC exhibite.....
Document: The above data suggest that epithelial de-differentiation or remodeling affects the polarization of PAR-2 and may sensitize epithelial cells to protease allergens by allowing apical PAR-2 activation. We tested if other alterations of epithelial development and ciliogenesis cause this phenotype. We used cigarette smoke condensate (CSC), shown to inhibit ciliogenesis in nasal ALIs. 17 Human ALIs cultured in the presence of 10-30 µg/ml CSC exhibited impaired ciliogenesis at day 20 ( Supplementary Fig S11A-B) . Higher concentrations increased epithelial permeability, but barrier function remained intact up to 30 µg/ml CSC (Supplementary Fig S11C-D) .
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