Author: Tang, Hongtao; Lu, Xiaosheng; Qie, Shuyan; Xi, Jianing
Title: Thoughts on detecting tissue distribution of potential COVID-19 receptors Cord-id: xl4pzu2b Document date: 2020_8_12
ID: xl4pzu2b
Snippet: Aim: As a novel coronavirus, coronavirus disease 2019 (COVID-19) has caused a global epidemic. Many clinical data show that COVID-19 can not only cause viral pneumonia but also damage a variety of target organs. Materials & methods: We searched some open online datasets, such as Gene ORGANizer, the Human Protein Atlas and Pubmed, to explore the tissue distribution of potential COVID-19 receptors (ACE2, CD209, CLEC4M and BSG) in the human body. Results: The above potential COVID-19 receptors were
Document: Aim: As a novel coronavirus, coronavirus disease 2019 (COVID-19) has caused a global epidemic. Many clinical data show that COVID-19 can not only cause viral pneumonia but also damage a variety of target organs. Materials & methods: We searched some open online datasets, such as Gene ORGANizer, the Human Protein Atlas and Pubmed, to explore the tissue distribution of potential COVID-19 receptors (ACE2, CD209, CLEC4M and BSG) in the human body. Results: The above potential COVID-19 receptors were highly expressed in the lungs, intestine, kidney, liver, heart, testis, placenta, hematopoietic tissue and nerve tissue. Conclusion: It is speculated that they may be potentially high-risk organs susceptible to COVID-19 infection. It is expectant to provide some help for further research in the future.
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