Selected article for: "chain reaction and particularly PCR polymerase chain reaction"

Author: Ramirez‐Hinojosa, Juan Pablo; Rodriguez‐Sanchez, Yunuen; Romero‐Gonzalez, Angel Kaleb; Chavez‐Gutierrez, Marisol; Gonzalez‐Arenas, Nelly Raquel; Ibarra‐Arce, Aurora; Arroyo‐Escalante, Sara; Zavaleta‐Villa, Beatriz; Leon‐Juarez, Moises; Cruz‐Holguin, Victor Javier; Espinosa de los Monteros‐Perez, Luz Elena; Olivo‐Diaz, Angelica; Hernandez‐Castro, Rigoberto; Suarez‐Roa, Lourdes; Prado‐Calleros, Hector; Sierra‐Martinez, Octavio; Avila‐Ramirez, Guillermina; Flisser, Ana; Maravilla, Pablo; Romero‐Valdovinos, Mirza
Title: Association between cycle threshold (C (t)) values and clinical and laboratory data in inpatients with COVID‐19 and asymptomatic health workers
  • Cord-id: xlmitdi2
  • Document date: 2021_7_9
  • ID: xlmitdi2
    Snippet: In‐house assays for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR), are feasible alternatives, particularly in developing countries. Cycle threshold (C (t)) values obtained by qRT‐PCR were compared with clinical and laboratory data from saliva of inpatients with COVID‐19 and asymptomatic health workers (AHW) were studied. Saliva specimens from 58 inpatients confirmed by qRT‐PC
    Document: In‐house assays for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR), are feasible alternatives, particularly in developing countries. Cycle threshold (C (t)) values obtained by qRT‐PCR were compared with clinical and laboratory data from saliva of inpatients with COVID‐19 and asymptomatic health workers (AHW) were studied. Saliva specimens from 58 inpatients confirmed by qRT‐PCR for SARS‐CoV‐2 using nasopharyngeal specimens, and 105 AHW were studied by qRT‐PCR using three sets of primers for the N (N1, N2, and N3) gene of SARS‐CoV‐2, according to the CDC Diagnostic Panel protocol, showing a positivity of 88% for inpatients and 8% for AHW. Bivariate analysis revealed an association between C (t) < 38.0 values for N2 and mechanical ventilation assistance among patients (p = .013). In addition, values of aspartate‐transaminase, lactate dehydrogenase, and ferritin showed significant correlations with C (t) values of N1 and N3 genes in inpatients. Therefore, our results show that C (t) values correlate with some relevant clinical data for inpatients with COVID‐19.

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