Author: Ramirezâ€Hinojosa, Juan Pablo; Rodriguezâ€Sanchez, Yunuen; Romeroâ€Gonzalez, Angel Kaleb; Chavezâ€Gutierrez, Marisol; Gonzalezâ€Arenas, Nelly Raquel; Ibarraâ€Arce, Aurora; Arroyoâ€Escalante, Sara; Zavaletaâ€Villa, Beatriz; Leonâ€Juarez, Moises; Cruzâ€Holguin, Victor Javier; Espinosa de los Monterosâ€Perez, Luz Elena; Olivoâ€Diaz, Angelica; Hernandezâ€Castro, Rigoberto; Suarezâ€Roa, Lourdes; Pradoâ€Calleros, Hector; Sierraâ€Martinez, Octavio; Avilaâ€Ramirez, Guillermina; Flisser, Ana; Maravilla, Pablo; Romeroâ€Valdovinos, Mirza
Title: Association between cycle threshold (C (t)) values and clinical and laboratory data in inpatients with COVIDâ€19 and asymptomatic health workers Cord-id: xlmitdi2 Document date: 2021_7_9
ID: xlmitdi2
Snippet: Inâ€house assays for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) by quantitative reverseâ€transcription polymerase chain reaction (qRTâ€PCR), are feasible alternatives, particularly in developing countries. Cycle threshold (C (t)) values obtained by qRTâ€PCR were compared with clinical and laboratory data from saliva of inpatients with COVIDâ€19 and asymptomatic health workers (AHW) were studied. Saliva specimens from 58 inpatients confirmed by qRTâ€PC
Document: Inâ€house assays for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) by quantitative reverseâ€transcription polymerase chain reaction (qRTâ€PCR), are feasible alternatives, particularly in developing countries. Cycle threshold (C (t)) values obtained by qRTâ€PCR were compared with clinical and laboratory data from saliva of inpatients with COVIDâ€19 and asymptomatic health workers (AHW) were studied. Saliva specimens from 58 inpatients confirmed by qRTâ€PCR for SARSâ€CoVâ€2 using nasopharyngeal specimens, and 105 AHW were studied by qRTâ€PCR using three sets of primers for the N (N1, N2, and N3) gene of SARSâ€CoVâ€2, according to the CDC Diagnostic Panel protocol, showing a positivity of 88% for inpatients and 8% for AHW. Bivariate analysis revealed an association between C (t) < 38.0 values for N2 and mechanical ventilation assistance among patients (p = .013). In addition, values of aspartateâ€transaminase, lactate dehydrogenase, and ferritin showed significant correlations with C (t) values of N1 and N3 genes in inpatients. Therefore, our results show that C (t) values correlate with some relevant clinical data for inpatients with COVIDâ€19.
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