Author: Brian D Quinlan; Huihui Mou; Lizhou Zhang; Yan Gao; Wenhui He; Amrita Ojha; Mark S Parcells; Guangxiang Luo; Wenhui Li; Guocai Zhong; Hyeryun Choe; Michael Farzan
Title: The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement Document date: 2020_4_12
ID: fnguelau_17
Snippet: A vaccine against SARS-CoV-2 should, for several reasons, be easier to generate than those against many other viruses (Gralinski and Baric, 2015; Li, 2016) . First, coronaviruses have exceptionally large genomes compared to other RNA viruses, and, to avoid error catastrophe, their viral polymerase has acquired a proof-reading function. Thus any individual gene, for example that of the S protein, is likely to retain its original sequence over mult.....
Document: A vaccine against SARS-CoV-2 should, for several reasons, be easier to generate than those against many other viruses (Gralinski and Baric, 2015; Li, 2016) . First, coronaviruses have exceptionally large genomes compared to other RNA viruses, and, to avoid error catastrophe, their viral polymerase has acquired a proof-reading function. Thus any individual gene, for example that of the S protein, is likely to retain its original sequence over multiple replication cycles.
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