Author: Brian D Quinlan; Huihui Mou; Lizhou Zhang; Yan Gao; Wenhui He; Amrita Ojha; Mark S Parcells; Guangxiang Luo; Wenhui Li; Guocai Zhong; Hyeryun Choe; Michael Farzan
Title: The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement Document date: 2020_4_12
ID: fnguelau_42
Snippet: Error bars indicate range of two entry assays. (D) Pooled sera and pooled preimmune sera mixed with the indicated concentrations of ACE2-Ig were further combined with an ACE2-Ig variant bearing a rabbit-derived Fc domain (ACE2-rIg). Binding of the ACE2-rIg was monitored with an anti-rabbit Fc secondary antibody as determined by flow cytometry. Error bars indicate the range of two such measurements. Differences between day-0 and day-40 serum are s.....
Document: Error bars indicate range of two entry assays. (D) Pooled sera and pooled preimmune sera mixed with the indicated concentrations of ACE2-Ig were further combined with an ACE2-Ig variant bearing a rabbit-derived Fc domain (ACE2-rIg). Binding of the ACE2-rIg was monitored with an anti-rabbit Fc secondary antibody as determined by flow cytometry. Error bars indicate the range of two such measurements. Differences between day-0 and day-40 serum are significant (P < 0.001; two-way ANOVA) at all dilutions.
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