Author: Jason W. Westerbeck; Carolyn E. Machamer
Title: The Infectious Bronchitis Virus Coronavirus Envelope Protein Alters Golgi pH to Protect Spike Protein and Promote Release of Infectious Virus Document date: 2018_10_11
ID: amg5dice_1
Snippet: The majority of human coronaviruses (CoVs) cause mild disease phenotypes. However, when novel coronaviruses like severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV emerge from their animal reservoirs to infect humans they elicit a robust and aberrant immune response that can lead to a very serious and deadly pneumonia (1) (2) (3) . Importantly, there are no effective vaccines or therapeutics to treat thes.....
Document: The majority of human coronaviruses (CoVs) cause mild disease phenotypes. However, when novel coronaviruses like severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV emerge from their animal reservoirs to infect humans they elicit a robust and aberrant immune response that can lead to a very serious and deadly pneumonia (1) (2) (3) . Importantly, there are no effective vaccines or therapeutics to treat these CoVs. Efforts to develop long-term therapeutic strategies to combat novel, highly pathogenic CoVs will be aided by increased understanding of conserved viral mechanisms at the level of their cell and molecular biology.
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