Selected article for: "mutant resident strain and resident mutant strain"
Author: Joe Pharaon; Chris T. Bauch
Title: The Influence Of Social Behavior On Competition Between Virulent Pathogen Strains
  • Document date: 2018_4_4
    • ID: 6s27v6at_33
    Snippet: Surprisingly, there are parameter regimes where increasing the perceived severity of the resident strain (ω 1 ) allows the mutant strain to invade (Figure 2a-c) . This occurs across a nontrivial portion of parameter space 236 despite the fact that R 0,2 < R 0,1 . This regime shift occurs because a sufficiently high perceived severity ( 2 ) can allow the mutant strain to invade (Figure 2e-f) . We note again that, surprisingly, invasion can result.....
    Document: Surprisingly, there are parameter regimes where increasing the perceived severity of the resident strain (ω 1 ) allows the mutant strain to invade (Figure 2a-c) . This occurs across a nontrivial portion of parameter space 236 despite the fact that R 0,2 < R 0,1 . This regime shift occurs because a sufficiently high perceived severity ( 2 ) can allow the mutant strain to invade (Figure 2e-f) . We note again that, surprisingly, invasion can result 252 in the elimination of the resident strain if the perceived severity of the mutant strain is significantly higher 253 than that of the resident strain (ω 2 >> ω 1 ), but when the opposite applies, coexistence results. We have showed how adaptive social behaviour greatly impacts the evolution of virulence in a coupled 256 behaviour-disease model. If we neglect social behaviour, the basic reproductive numbers of the two strains 257 are sufficient to predict which of the strains will invade a population. However, adding adaptive social 258 behaviour with asymmetric stimulation and effects on either strain to an epidemiological system completely 259 shifts how we view whether a more virulent strain will be selected for. As we have seen, social behaviour

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