Author: Levy, Joshua M.; Frediani, Jennifer K.; Tyburski, Erika A.; Wood, Anna; Figueroa, Janet; Kempker, Russell R.; Rebolledo, Paulina A.; Gonzalez, Mark D.; Sullivan, Julie; Vos, Miriam B.; O’Neal, Jared; Martin, Greg S.; Lam, Wilbur A.; Waggoner, Jesse J.
Title: Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2 Cord-id: yofjfn2i Document date: 2021_7_21
ID: yofjfn2i
Snippet: The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74
Document: The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88–1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.
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