Author: de Candia, Paola; Prattichizzo, Francesco; Garavelli, Silvia; Matarese, Giuseppe
Title: T Cells: Warriors of SARS-CoV-2 Infection Cord-id: z9vjo98p Document date: 2020_11_13
ID: z9vjo98p
Snippet: Severe infection with SARS-CoV-2 is characterized by massive cytokine release and T cell loss. The exaggerated host immune response, incapable of viral clearance, instead aggravates respiratory distress, as well as cardiac and/or damage to other organs. The mortality pattern of SARS-CoV-2 infection, higher in older vs younger adults and almost absent in children, is possibly caused by the effects of age and pre-existing co-morbidities on innate and adaptive immunity. Here, w speculate that the a
Document: Severe infection with SARS-CoV-2 is characterized by massive cytokine release and T cell loss. The exaggerated host immune response, incapable of viral clearance, instead aggravates respiratory distress, as well as cardiac and/or damage to other organs. The mortality pattern of SARS-CoV-2 infection, higher in older vs younger adults and almost absent in children, is possibly caused by the effects of age and pre-existing co-morbidities on innate and adaptive immunity. Here, w speculate that the abnormal and excessive immune response to SARS-CoV-2 infection partly depends on T cell immunological memory, that is more pronounced in adults compared to children, and may significantly contribute to immunopathology and massive collateral damage in COVID-19 patients.
Search related documents:
Co phrase search for related documents- activation cleavage and adaptive immunity: 1
- activation high viral replication and adaptive immunity: 1
- activation marker and acute sars infection: 1, 2, 3, 4
- activation marker and adaptive immune cell: 1, 2
- activation marker and adaptive immune response: 1
- activation marker and adaptive immunity: 1, 2, 3, 4
- activation marker and adaptive response: 1
- activation status and acute sars infection: 1, 2
- activation status and adaptive immune cell: 1, 2
- activation status and adaptive immune response: 1, 2
- activation status and adaptive immunity: 1, 2, 3, 4
- activation status and adaptive response: 1, 2
- active viral replication and acute sars infection: 1, 2, 3, 4
- acute sars infection and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- acute sars infection and adaptive immunity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute sars infection and adaptive memory: 1, 2
- acute sars infection and adaptive response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- acute sars infection and additional risk factor: 1
Co phrase search for related documents, hyperlinks ordered by date