Nature and Duration of Protective Antibodies Developed After COVID-19 Infection: Journal of Pediatric Infection

Turan, Cansu Haamustafaoǧlu Mustafa

The specificity of tests that measure IgG antibody or IgM+IgG total antibodies is much higher than tests that measure IgM or IgA antibodies alone. [...]the measurement of IgA antibody level is not recommended for routine use. The Centers for Disease Control and Prevention (CDC) recommends that antibody tests with high specificity (99.5%) should be preferred primarily in the diagnosis of COVID-19. [...]the high sensitivity of the test used (the positive rate of a given test in a PCR confirmed COVID-19 patient) and high specificity (the negative rate of a given test in a patient without COVID-19) increases the accuracy of the test used. [...]it can be predicted that SARS CoV-2 infection with systemic symptoms may also lead to a longer-lasting immune response. [...]Roche Elecsys Anti-SARS-CoV-2 total semi-quantitative/qualitative test results with COI (cut-off index) level >109, Roche Elecsys Anti-SARS-CoV-2 quantitative total antibody test with level >132 IU/mL, Euroimmune anti-SARS-CoV-IgG semi-quantitative/qualitative test with ratio >3.5, determined as acceptable high antibody values, for the convalescent plasma pool.