Author: Dal-Ré, Rafael; Porcher, Raphaël; Gluud, Christian
Title: COVID-19 clinical trials: ethical and scientific consequences of the RECOVERY trial results. Cord-id: zmo3rgsy Document date: 2020_9_15
ID: zmo3rgsy
Snippet: The COVID-19 pandemic has spurred tremendous activity in clinical drug investigations worldwide. One large trial that may influence other trials is the RECOVERY trial, an open-label, adaptive, multi-arm, randomized clinical trial (RCT) assessing experimental medicines versus standard of care (SOC) in COVID-19 hospitalized patients, and with mortality as principal endpoint. Preliminary RECOVERY trial results have shown that dexamethasone reduced death rate in certain patients' subgroups (positive
Document: The COVID-19 pandemic has spurred tremendous activity in clinical drug investigations worldwide. One large trial that may influence other trials is the RECOVERY trial, an open-label, adaptive, multi-arm, randomized clinical trial (RCT) assessing experimental medicines versus standard of care (SOC) in COVID-19 hospitalized patients, and with mortality as principal endpoint. Preliminary RECOVERY trial results have shown that dexamethasone reduced death rate in certain patients' subgroups (positive results), whereas both hydroxychloroquine and lopinavir/ritonavir produced no benefit (negative results) versus SOC.
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