Author: Hazel Stewart; Katherine Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth
Title: The transcriptional and translational landscape of equine torovirus Document date: 2018_4_7
ID: mozfm5ds_34
Snippet: We therefore extended the bioinformatics analysis using all eight currently available 326 torovirus genome sequences ( Figure 9 ). Since the U2 ORF overlaps ORF1a, leading to 327 constraint on dS, the dN/dS analysis is not appropriate for U2. MLOGD analysis 328 indicated that the U2 ORF has a higher coding potential than the corresponding part 329 of ORF1a ( Figure 9 ). Overlapping genes are thought mainly to evolve through 330 "overprinting" of .....
Document: We therefore extended the bioinformatics analysis using all eight currently available 326 torovirus genome sequences ( Figure 9 ). Since the U2 ORF overlaps ORF1a, leading to 327 constraint on dS, the dN/dS analysis is not appropriate for U2. MLOGD analysis 328 indicated that the U2 ORF has a higher coding potential than the corresponding part 329 of ORF1a ( Figure 9 ). Overlapping genes are thought mainly to evolve through 330 "overprinting" of an ancestral gene by the de novo gene (25). The de novo gene 331 product is often an accessory protein and often disordered (26). Interestingly, the 332 fragment of pp1a encoded by the region of ORF1a that is overlapped by U2 has no 333 tblastn (27) The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/296996 doi: bioRxiv preprint probability that the observed level of conservation would occur by chance is p = 6.5 x 344 10 −40 . 345
Search related documents:
Co phrase search for related documents- accessory protein and genome sequence: 1, 2, 3
- accessory protein and overlapping gene: 1
- ancestral gene and de novo gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- ancestral gene and genome sequence: 1
- ancestral gene and overlapping gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- bioinformatic analysis and genome sequence: 1, 2, 3, 4, 5
- chance occur and genome sequence: 1
- conservation observed level and observed level: 1
- de novo gene and genome sequence: 1, 2, 3
- de novo gene and overlapping gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- genome sequence and observed level: 1
- genome sequence and ORF1a overlap: 1, 2, 3, 4
- genome sequence and ORF1a region: 1, 2, 3, 4, 5, 6, 7, 8, 9
- genome sequence and overlapping gene: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- observed level and ORF1a overlap: 1
- ORF1a overlap and overlapping gene: 1
Co phrase search for related documents, hyperlinks ordered by date