Selected article for: "CUG codon and initiation context"

Author: Hazel Stewart; Katherine Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth
Title: The transcriptional and translational landscape of equine torovirus
  • Document date: 2018_4_7
  • ID: mozfm5ds_35
    Snippet: Both U1 and U2 are conserved in all eight torovirus sequences with no variation in 346 length or initiation or termination position (Supplementary Figure 5) . In all 347 sequences, U1 and U2 begin with a CUG codon in a strong initiation context ('A' at -3 348 for U1, and 'A' at -3 and 'G' at +4 for U2) (30). The U1 protein is predicted to contain 349 two central transmembrane domains and has a C-terminus containing many charged 350 amino acids. T.....
    Document: Both U1 and U2 are conserved in all eight torovirus sequences with no variation in 346 length or initiation or termination position (Supplementary Figure 5) . In all 347 sequences, U1 and U2 begin with a CUG codon in a strong initiation context ('A' at -3 348 for U1, and 'A' at -3 and 'G' at +4 for U2) (30). The U1 protein is predicted to contain 349 two central transmembrane domains and has a C-terminus containing many charged 350 amino acids. The U2 protein is predicted to form alternating α helix and antiparallel β 351 sheet domains, however no structural homologs were found through searches of 352 public databases (31-33). Their function(s) will be the topic of future work. Figure 6 ) and it has been suggested previously that the motif 366 definition should be extended to cACN 3-4 CUUUAGA to reflect this (34). It is likely that 367 these flanking nucleotides contribute to the degree of utilisation. 368

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