A role for Streptococcus pneumoniae in virus-associated pneumonia

Madhi, Shabir A; Klugman, Keith P; The Vaccine Trialist Group

Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15–43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia. NOTE: In the version of this article originally published online, the species name was misspelled Streptococcus pnemoniae in the title of the article. The name should be Streptococcus pneumoniae . This error has been corrected for the HTML and print versions of the article. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nm1077) contains supplementary material, which is available to authorized users.