Author: Randall Toy; Pallab Pradhan; Vijayeetha Ramesh; Nelson C. Di Paolo; Blake Lash; Jiaying Liu; Emmeline L. Blanchard; Philip J. Santangelo; Dmitry M. Shayakhmetov; Krishnendu Roy
Title: Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways Document date: 2019_5_24
ID: cbit5xci_61
Snippet: Remarkably, IAA was able to downregulate several biomarkers of in vivo systemic toxicity to bPEI nanoparticles. The IAA modification reduced liver toxicity, IL-6 production, and CXCL1 production after intravenous administration. Reduced toxicity may be attributed to changes in the protein corona, in which fibrinogen binding to PEI nanoparticles was significantly reduced after IAA modification......
Document: Remarkably, IAA was able to downregulate several biomarkers of in vivo systemic toxicity to bPEI nanoparticles. The IAA modification reduced liver toxicity, IL-6 production, and CXCL1 production after intravenous administration. Reduced toxicity may be attributed to changes in the protein corona, in which fibrinogen binding to PEI nanoparticles was significantly reduced after IAA modification.
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