Author: Hazel Stewart; Katherine Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth
Title: The transcriptional and translational landscape of equine torovirus Document date: 2018_4_7
ID: mozfm5ds_56
Snippet: ORF1a coding capacity in another frame. U1 is not under such limitations, although it 496 is likely that the viral genome must maintain specific 5' UTR structures to facilitate 497 viral replication. Previous investigations utilising defective interfering RNAs have 498 confirmed that no more than the first 604 nt of the 5' UTR and the entirety of the 3' 499 UTR are sufficient to allow both positive and minus strand RNA synthesis (34); it is 500 n.....
Document: ORF1a coding capacity in another frame. U1 is not under such limitations, although it 496 is likely that the viral genome must maintain specific 5' UTR structures to facilitate 497 viral replication. Previous investigations utilising defective interfering RNAs have 498 confirmed that no more than the first 604 nt of the 5' UTR and the entirety of the 3' 499 UTR are sufficient to allow both positive and minus strand RNA synthesis (34); it is 500 notable that this region only includes one-third of the U1 ORF (which starts at 501 nucleotide 524) and hence only this subdomain would be constrained by maintaining 502 two distinct functional roles. We suggest that the so-called 5' UTR is actually limited 503 to 523 nt preceding the CUG of U1, and the remainder of U1 and U2 is not under 504 pressure to maintain cis-replication elements. 505
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