The within-host viral kinetics of SARS-CoV-2

Chentong Li; Jinhu Xu; Jiawei Liu; Yicang Zhou

where D i is the smoothed chest radiograph score of the serve patient at time The copyright holder for this preprint (which was not peer-reviewed) is the . which is larger than the clearance rate of the virus on the outside surface [4] . This result shows the immune system can clear the virus directly. The estimation result also shows that the R 0 of SARS-CoV-2 in serve patients is around the mean value 3.79 which is lower than that of MERS virus (8.16) . These results illustrate that the immune system can not clear the virus effectively at the beginning time of symptom onset. By these estimated parameters of COVID-19, the solutions of model (1) are illustrated in Figure . 2. The partial rank correlation coefficient (PRCC) method [9] is used to do the sensitivity analysis of R 0 . The result ( Figure . 3) shows that the parameters E p (0), β, π v , d E * , and d v have almost the same level of influence on R 0 . Parameters d E * , and d v have negative correlations with R 0 , while E p (0), β, π v have positive correlations. The positive correlation of E p (0) with R 0 may give a explanation on why the babys, who have small amount of pulmonary epithelial cells, are not likely to get infected and have lower mortality ( [15] Table 1 ).