Author: Jrhau Lung; Yu-Shih Lin; Yao-Hsu Yang; Yu-Lun Chou; Geng-He Chang; Ming-Shao Tsai; Cheng-Ming Hsu; Reming-Albert Yeh; Li-Hsin Shu; Yu-Ching Cheng; Hung Te Liu; Ching-Yuan Wu
Title: The potential SARS-CoV-2 entry inhibitor Document date: 2020_3_26
ID: 7w79zeib_6
Snippet: In a recent study, we discovered that theaflavin possesses a potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase (9) . Some Chinese medicinal compounds are also used for prophylaxis of SARS-CoV-2 infection. However, the actual mechanisms and efficiency of theaflavin for inhibiting SARS-CoV-2 entry into host cells are still unclear. Therefore, we used molecular docking to target the RBD of SARS-CoV-2, with the aim of scree.....
Document: In a recent study, we discovered that theaflavin possesses a potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase (9) . Some Chinese medicinal compounds are also used for prophylaxis of SARS-CoV-2 infection. However, the actual mechanisms and efficiency of theaflavin for inhibiting SARS-CoV-2 entry into host cells are still unclear. Therefore, we used molecular docking to target the RBD of SARS-CoV-2, with the aim of screening these chemical structures of traditional Chinese medicinal compounds demonstrating commonly used against SARS-CoV and identifying alternative potential chemical structures for antiviral therapy.
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