Author: Chiu, Charles Y.; Rouskin, Silvi; Koshy, Anita; Urisman, Anatoly; Fischer, Kael; Yagi, Shigeo; Schnurr, David; Eckburg, Paul B.; Tompkins, Lucy S.; Blackburn, Brian G.; Merker, Jason D.; Patterson, Bruce K.; Ganem, Don; DeRisi, Joseph L.
Title: Microarray Detection of Human Parainfluenzavirus 4 Infection Associated with Respiratory Failure in an Immunocompetent Adult Cord-id: ci4qg0qu Document date: 2006_10_15
ID: ci4qg0qu
Snippet: A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray results were confirmed by specific polymerase chain reaction and serological analysis for HPIV-4. Conventional clinical laboratory testing using an extensive panel of microbiologi
Document: A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness. The virus was identified in an endotracheal aspirate specimen, and the microarray results were confirmed by specific polymerase chain reaction and serological analysis for HPIV-4. Conventional clinical laboratory testing using an extensive panel of microbiological tests failed to yield a diagnosis. This case suggests that the potential severity of disease caused by HPIV-4 in adults may be greater than previously appreciated and illustrates the clinical utility of a microarray for broad-based viral pathogen screening.
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