Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases

Lulin Zhou; Zubiao Niu; Xiaoyi Jiang; Zhengrong Zhang; You Zheng; Zhongyi Wang; Yichao Zhu; Lihua Gao; Xiaoning Wang; Qiang Sun

The copyright holder for this preprint (which was not peer-reviewed) is the . this study, and also the nasal epithelial cells as reported recently [19] . And the likelihood for epithelial cells in digestive and urinary system as the primary target are low. During the period of viremia if there was, the top internal organ targets would be cardiomyocytes, and stromal cells in adrenal gland, both of them express all three ACE2, TMPRSS2 and Furin proteases; the descent targets may be Leydig cells in testis, and stromal cells in ovary and thyroid gland, these cells are un-polarized and ACE2-positve, but don't show ideal co-expression of TMPRSS2 or Furin proteases.