Author: Yan Li; Jinyong Zhang; Ning Wang; Haibo Li; Yun Shi; Gang Guo; Kaiyun Liu; Hao Zeng; Quanming Zou
Title: Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening Document date: 2020_1_29
ID: iu2ziccm_37
Snippet: Although coronaviruses are under extensive mutagenesis, some key proteins, especially replication-related enzymes, are highly conserved [8] . Because the mutation in key proteins are often lethal to the virus [9] , drugs that target conservative protease are usually capable of preventing the replication and proliferation of the virus and exhibit broad spectrum. Besides, they can reduce the risk of mutation mediated drug-resistance......
Document: Although coronaviruses are under extensive mutagenesis, some key proteins, especially replication-related enzymes, are highly conserved [8] . Because the mutation in key proteins are often lethal to the virus [9] , drugs that target conservative protease are usually capable of preventing the replication and proliferation of the virus and exhibit broad spectrum. Besides, they can reduce the risk of mutation mediated drug-resistance.
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