Author: Shay Leary; Silvana Gaudieri; Abha Chopra; Suman Pakala; Eric Alves; Mina John; Suman Das; Simon Mallal; Phillips Jane Phillips
Title: Three adjacent nucleotide changes spanning two residues in SARS-CoV-2 nucleoprotein: possible homologous recombination from the transcription-regulating sequence Document date: 2020_4_11
ID: 9xueqdri_5
Snippet: The polymorphisms are present in strains sequenced using different next generation sequencing (NGS) platforms (e.g. nanopore, Illumina) and the Sanger-based sequencing method making it unlikely that the new changes are sequence or alignment errors. In addition, different laboratories around the world have deposited sequences with these polymorphisms in the database and examination of individual sequences in the region does not find obvious insert.....
Document: The polymorphisms are present in strains sequenced using different next generation sequencing (NGS) platforms (e.g. nanopore, Illumina) and the Sanger-based sequencing method making it unlikely that the new changes are sequence or alignment errors. In addition, different laboratories around the world have deposited sequences with these polymorphisms in the database and examination of individual sequences in the region does not find obvious insertions/deletions likely representing alignment issues or homopolymer slippage.
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