Author: Dai, Yifei; Qiang, Weijie; Gui, Yu; Tan, Xue; Pei, Tianli; Lin, Kequan; Cai, Siwei; Sun, Liang; Ning, Guochen; Wang, Jianxun; Guo, Hongyan; Sun, Yimin; Cheng, Jing; Xie, Lan; Lan, Xun; Wang, Dong
Title: A large-scale transcriptional study reveals inhibition of COVID-19 related cytokine storm by traditional chinese medicines Cord-id: 8msh8cmd Document date: 2021_1_12
ID: 8msh8cmd
Snippet: Coronavirus disease-2019 (COVID-19) has become a major global epidemic. Facilitated by HTS(2) technology, we evaluated the effects of 578 herbs and all 338 reported anti-COVID-19 TCM formulae on cytokine storm-related signaling pathways, and identified the key targets of the relevant pathways and potential active ingredients in these herbs. This large-scale transcriptional study innovatively combines HTS(2) technology with bioinformatics methods and computer-aided drug design. For the first time
Document: Coronavirus disease-2019 (COVID-19) has become a major global epidemic. Facilitated by HTS(2) technology, we evaluated the effects of 578 herbs and all 338 reported anti-COVID-19 TCM formulae on cytokine storm-related signaling pathways, and identified the key targets of the relevant pathways and potential active ingredients in these herbs. This large-scale transcriptional study innovatively combines HTS(2) technology with bioinformatics methods and computer-aided drug design. For the first time, it systematically explores the molecular mechanism of TCM in regulating the COVID-19-related cytokine storm, providing an important scientific basis for elucidating the mechanism of action of TCM in treating COVID-19. [Figure: see text]
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