Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application.

Uddin, Ekhlass; Islam, Raisul; Ashrafuzzaman,; Bitu, Nur Amin; Hossain, Md Saddam; Islam, Abm Nazmul; Asraf, Ali; Hossen, Faruk; Mohapatra, Ranjan K; Kudrat-E-Zahan, Md

Coronaviruses (CoVs) belonging to the Betacoronavirus group, an unusually large RNA genome, are characterized by club-like spikes that project from their surface. An outbreak of a novel coronavirus 2019 (nCOVID-19) showing a unique replication strategy and infection has posed a significant threat to international health and the economy around the globe. Scientists around the world are investigating few previously used clinical drugs for the treatment of COVID-19. This review provides synthesis and mode of action of recently investigated drugs like Chloroquine, Hydroxychloroquine, Ivermectin, Selamectin, Remdesivir, Baricitinib, Darunavir, Favipiravir, Lopinavir/ritonavir and Mefloquine hydrochloride that constitute an option for COVID-19 treatment.