Selected article for: "activity broad spectrum and broad spectrum"
Author: Yan Li; Jinyong Zhang; Ning Wang; Haibo Li; Yun Shi; Gang Guo; Kaiyun Liu; Hao Zeng; Quanming Zou
Title: Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening
  • Document date: 2020_1_29
    • ID: iu2ziccm_39
    Snippet: Among the four molecules identified in this study, Prulifloxacin is a chemotherapeutic fluoroquinolone antibiotic with broad-spectrum activity, it has been approved for the treatment of uncomplicated and complicated urinary tract infections, community-acquired respiratory tract infections in Italy and gastroenteritis, including infectious diarrheas, in Japan [10] . Unfortunately, Prulifloxacin is reported as a prodrug, which is rapidly metabolize.....
    Document: Among the four molecules identified in this study, Prulifloxacin is a chemotherapeutic fluoroquinolone antibiotic with broad-spectrum activity, it has been approved for the treatment of uncomplicated and complicated urinary tract infections, community-acquired respiratory tract infections in Italy and gastroenteritis, including infectious diarrheas, in Japan [10] . Unfortunately, Prulifloxacin is reported as a prodrug, which is rapidly metabolized to ulifloxacin in vivo [11] . But it can be used as a lead compound that provide guidance for our later structural modification and optimization to design more effective main protease inhibitors. Tegobuvir is a novel author/funder. All rights reserved. No reuse allowed without permission.

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