Nucleoside-modified messenger RNA (modRNA) COVID-19 vaccine platform.

Roncati, Luca; Corsi, Lorenzo

On March 11, 2020, the World Health Organization declared Coronavirus Disease 19 (COVID-19) a pandemic; from that date the vaccine race has begun, and many technology platforms to develop a specific and effective COVID-19 vaccine have been launched in several clinical trials (protein subunit, RNA-based, DNA-based, replicating viral vector, non-replicating viral vector, inactivated virus, live attenuated virus and virus-like particle). Among the next-generation strategies, nucleoside-modified messenger RNA (modRNA) vaccines appear the most attractive, not only to counteract emerging pathogens, but also for the possible applications in regenerative medicine and cancer therapy. However, exactly as all innovative drugs, they deserve a careful pharmacovigilance in the short and long term. This article is protected by copyright. All rights reserved.