Author: Ragoonanan, Dristhi; Khazal, Sajad J.; Mejia, Rodrigo; Ewing, Linette; Durand, Jean-Bernard; Bashoura, Lara; Tayar, Jean; Dailey Garnes, Natalie; Petropoulos, Demetrios; Tewari, Priti; Bhatti, Micah; Ahmad, Ali Haider; Cortes, Jose; Razvi, Shehla; McBeth, Katrina; Swinford, Rita; Shoberu, Basirat; Waseemuddin, Waseem; Chi, Linda; Gill, Jonathan B.; Zaky, Wafik; Daw, Najat; Gutierrez, Cristina; Tereffe, Welela; Kebriaei, Partow; Rezvani, Katayoun; Shpall, Elizabeth J.; Champlin, Richard E.; Mahadeo, Kris M.
Title: Case Discussion and Literature Review: Cancer Immunotherapy, Severe Immune-Related Adverse Events, Multi-Inflammatory Syndrome, and Severe Acute Respiratory Syndrome Coronavirus 2 Cord-id: 6boex39m Document date: 2021_2_4
ID: 6boex39m
Snippet: Pediatric, adolescent and young adult (AYA) patients receiving novel cancer immunotherapies may develop associated toxicities with overlapping signs and symptoms that are not always easily distinguished from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection/clinical sequelae. We describe 2 diagnostically challenging cases of SARS-CoV-2 and Multi-Inflammatory Syndrome-Adult (MIS-A), in patients with a history of acute lymphoblastic leukemia following cellular therapy administ
Document: Pediatric, adolescent and young adult (AYA) patients receiving novel cancer immunotherapies may develop associated toxicities with overlapping signs and symptoms that are not always easily distinguished from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection/clinical sequelae. We describe 2 diagnostically challenging cases of SARS-CoV-2 and Multi-Inflammatory Syndrome-Adult (MIS-A), in patients with a history of acute lymphoblastic leukemia following cellular therapy administration and review evolving characterization of both the natural course of SARS-CoV-2 infection and toxicities experienced in younger cancer immunotherapy patients. Vigilant monitoring for unique presentations and epidemiologic surveillance to promptly detect changes in incidence of either condition may be warranted.
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