Author: Aravinth Kumar Jayabalan; Diane E. Griffin; Anthony K. L. Leung
Title: Alphavirus nsP3 ADP-ribosylhydrolase Activity Disrupts Stress Granule Formation Document date: 2019_6_20
ID: n8sjpcbs_4
Snippet: Intriguingly, nsP3 expression also suppresses the formation of and disassembles SG-like aggregates induced by a pathological mutant of the RNA-binding protein FUS (R495X) from an aggressive form of ALS [48, 49] . These data altogether suggest that nsP3 ADP-ribosylhydrolase activity is able to disrupt SG formation in both physiological and pathological conditions......
Document: Intriguingly, nsP3 expression also suppresses the formation of and disassembles SG-like aggregates induced by a pathological mutant of the RNA-binding protein FUS (R495X) from an aggressive form of ALS [48, 49] . These data altogether suggest that nsP3 ADP-ribosylhydrolase activity is able to disrupt SG formation in both physiological and pathological conditions.
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