Author: Antonio Gonçalves; Julie Bertrand; Ruian Ke; Emmanuelle Comets; Xavier de Lamballerie; Denis Malvy; Andrés Pizzorno; Olivier Terrier; Manuel Rosa Calatrava; France Mentré; Patrick Smith; Alan S Perelson; Jérémie Guedj
Title: Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load Document date: 2020_4_7
ID: n6l2804j_21
Snippet: These numbers also inform us both on the time to initiate antiviral treatment, and the 158 level of efficacy that needs to be achieved to reduce viral load [6] . As limited information is 159 available on the mechanisms leading to viral clearance, and how they may be modulated by 160 treatment, we used our model to predict the effects of treatment at day 5 post symptoms, 161 which corresponds to the time the viral load tends to peak in the absenc.....
Document: These numbers also inform us both on the time to initiate antiviral treatment, and the 158 level of efficacy that needs to be achieved to reduce viral load [6] . As limited information is 159 available on the mechanisms leading to viral clearance, and how they may be modulated by 160 treatment, we used our model to predict the effects of treatment at day 5 post symptoms, 161 which corresponds to the time the viral load tends to peak in the absence of treatment [3] . We 162 considered a simple case where the drug effectiveness is assumed to be constant after therapy 163 initiation (see methods) and we calculated the minimal efficacy that would be needed to 164 generate more than 2 logs of viral decline at peak viral load in the 13 studied patients (Fig. 1) . 165
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