Author: Courtney Mycroft-West; Dunhao Su; Stefano Elli; Scott Guimond; Gavin Miller; Jeremy Turnbull; Edwin Yates; Marco Guerrini; David Fernig; Marcelo Lima; Mark Skidmore
Title: The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding Document date: 2020_3_2
ID: 0d77ojnb_28
Snippet: Such drugs will be amenable to routine parenteral administration through currently established routes and additionally, direct to the respiratory tract via nasal administration, using nebulised heparin, which would be unlikely to gain significant access to the circulation. Thus, the anticoagulant activity of heparin, which can in any event be engineered out, would not pose a problem. Importantly, such a route of administration would not only be s.....
Document: Such drugs will be amenable to routine parenteral administration through currently established routes and additionally, direct to the respiratory tract via nasal administration, using nebulised heparin, which would be unlikely to gain significant access to the circulation. Thus, the anticoagulant activity of heparin, which can in any event be engineered out, would not pose a problem. Importantly, such a route of administration would not only be suitable for prophylaxis, but also for patients under mechanical ventilation 19 . the author/funder. All rights reserved. No reuse allowed without permission.
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