Author: Dorothea Bestle; Miriam Ruth Heindl; Hannah Limburg; Thuy Van Lam van; Oliver Pilgram; Hong Moulton; David A. Stein; Kornelia Hardes; Markus Eickmann; Olga Dolnik; Cornelius Rohde; Stephan Becker; Hans-Dieter Klenk; Wolfgang Garten; Torsten Steinmetzer; Eva Böttcher-Friebertshäuser
Title: TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets Document date: 2020_4_15
ID: anedg12x_27
Snippet: CoV S lacks the 4-mer insertion at the S1/S2 site ( Fig. 1B; Walls et al., 2020) . The S protein 446 of MERS-CoV contains a dibasic motif of the sequence R-X-X-R at both S1/S2 and S2' site. Thus, combination of protease inhibitors (e.g. aprotinin or camostat) and antivirals provides a 537 promising approach to block SARS-CoV-2 replication that should be tested in cell cultures 538 and animal models and should furthermore be considered as therapeu.....
Document: CoV S lacks the 4-mer insertion at the S1/S2 site ( Fig. 1B; Walls et al., 2020) . The S protein 446 of MERS-CoV contains a dibasic motif of the sequence R-X-X-R at both S1/S2 and S2' site. Thus, combination of protease inhibitors (e.g. aprotinin or camostat) and antivirals provides a 537 promising approach to block SARS-CoV-2 replication that should be tested in cell cultures 538 and animal models and should furthermore be considered as therapeutic strategy for the 539 treatment of COVID-19. 540
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