Author: Dorothea Bestle; Miriam Ruth Heindl; Hannah Limburg; Thuy Van Lam van; Oliver Pilgram; Hong Moulton; David A. Stein; Kornelia Hardes; Markus Eickmann; Olga Dolnik; Cornelius Rohde; Stephan Becker; Hans-Dieter Klenk; Wolfgang Garten; Torsten Steinmetzer; Eva Böttcher-Friebertshäuser
Title: TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets Document date: 2020_4_15
ID: anedg12x_28
Snippet: In summary, we demonstrate that TMPRSS2 and furin are essential for activation and 541 The cDNA encoding the SARS-CoV-2 spike protein of isolate Wuhan-Hu-1 (GenBank 572 accession number MN908947; codon-optimized, sequence available upon request) with a C-573.....
Document: In summary, we demonstrate that TMPRSS2 and furin are essential for activation and 541 The cDNA encoding the SARS-CoV-2 spike protein of isolate Wuhan-Hu-1 (GenBank 572 accession number MN908947; codon-optimized, sequence available upon request) with a C-573
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