Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation Document date: 2019_7_22
ID: gg2ctmn7_1
Snippet: Chronic obstructive pulmonary disease (COPD) is an inflammatory airway disorder punctuated by acute exacerbations, frequently precipitated by rhinoviruses (RVs) 1,2 . Exacerbations are the major cause of morbidity and mortality in COPD 3, 4 and a greater understanding of the underlying pathophysiological mechanisms is urgently needed to facilitate development of new therapies to reduce the impact of these debilitating episodes......
Document: Chronic obstructive pulmonary disease (COPD) is an inflammatory airway disorder punctuated by acute exacerbations, frequently precipitated by rhinoviruses (RVs) 1,2 . Exacerbations are the major cause of morbidity and mortality in COPD 3, 4 and a greater understanding of the underlying pathophysiological mechanisms is urgently needed to facilitate development of new therapies to reduce the impact of these debilitating episodes.
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