Author: Esther S. Brielle; Dina Schneidman-Duhovny; Michal Linial
Title: The SARS-CoV-2 exerts a distinctive strategy for interacting with the ACE2 human receptor Document date: 2020_3_12
ID: jpkxjn6e_3
Snippet: While the sequence identity between the RBDs of COVID-19 and SARS-2002 is 73% (Table 1) , we observe a significantly higher residue substitution rate at the interaction interface with the ACE2 receptor. Out of 29 RBD interface residues, only 10 residues (34%) in COVID-19 are conserved with respect to SARS-2002 ( Fig. 2A, Table S1, Fig. S1 ). Similarly, only 12 residues (40%) in SARS-2002 are conserved with respect to COVID-19......
Document: While the sequence identity between the RBDs of COVID-19 and SARS-2002 is 73% (Table 1) , we observe a significantly higher residue substitution rate at the interaction interface with the ACE2 receptor. Out of 29 RBD interface residues, only 10 residues (34%) in COVID-19 are conserved with respect to SARS-2002 ( Fig. 2A, Table S1, Fig. S1 ). Similarly, only 12 residues (40%) in SARS-2002 are conserved with respect to COVID-19.
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