Author: Alisher M Kariev; Michael E Green
Title: The Role of Proton Transport in Gating Current in a Voltage Gated Ion Channel, as Shown by Quantum Calculations Document date: 2018_7_19
ID: cyxdy7hg_27
Snippet: However, for the type of channels we are discussing here, the value of Q 10 in the physiological temperature range tends to be a little less than 2 for conduction, and approximately 4 for open probability. For the temperature sensing TRP channels. the mechanism of gating must be different; it appears so steep a temperature dependence requires a cooperative mechanism (but see(100) for a proposed mechanism). There is no evidence that gating in the .....
Document: However, for the type of channels we are discussing here, the value of Q 10 in the physiological temperature range tends to be a little less than 2 for conduction, and approximately 4 for open probability. For the temperature sensing TRP channels. the mechanism of gating must be different; it appears so steep a temperature dependence requires a cooperative mechanism (but see(100) for a proposed mechanism). There is no evidence that gating in the non-TRP channels is cooperative, and no direct evidence that pertains to TRP channels either.
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